S-equol is backed by decades of research†
Therapeutic Interest in S-equol
First demonstration that S-equol can be used to treat estrogen-mediated conditions.
Setchell KD, et al. Am J Clin Nutr. 1984;40:569–78.
Soy Protective for Health
WHO CARDIAC Study explores the relationship between diet and longevity–focusing particularly on soybeans and women’s health.
Soy Reduces Menopause Symptoms
Post–menopausal women who consumed soy flour experienced fewer menopause symptoms compared to baseline.
Murkies AL, et al. Maturitas. 1995;21(3):189-95.
Lactic acid bacteria that produces S-equol identified in fermented soybean germ.
How S-equol is Metabolized
Review of how daidzein, a soy isoflavone, is metabolized to equol.
Atkinson C, et al. Experimental biology and medicine. 2005;230(3):155-70.
S-equol Correlated with Reduced Symptoms
Correlational analysis suggesting more equol production linked to reduced symptoms.
Uchiyama S, et al. J Jpn Menopause Soc. 2007; 15:28-37.
S-equol Improves Mood
Women taking S-equol improved on 4 of the 6 POMS (profile of moods) categories compared to placebo.
Ishiwata N, et al. Menopause. 2009; 16:141-148.
A 12-Week randomized, double-blind, placebo-controlled trial with 134 women, ranging peri- to post-menopausal, aged 40–59 years.
S-equol Reduces Vasomotor Symptoms
S-equol reduced hot flashes and shoulder and neck stiffness compared to placebo.
Aso T, et al. J of Women's Health. 2012;21(1):92-100.
A 12-Week, double-blind placebo-controlled trial of 160 post-menopausal women who experienced at least one hot flash a day.
S-equol significantly reduced hot flash frequency, compared to baseline. Additionally, S-equol was more effective for relieving muscle and joint pain than placebo (soy isoflavone).
Jenks B, et al. J of Women's Health. 2012; 21(6):674-82.
An 8-Week randomized, double-blind trial with 102 post-menopausal women, aged 45–65 years, who experienced approximately 5 hot flashes/day.
EQUELLE first launches in Japan.
United States Launch
EQUELLE is now widely available in the United States.
EQUELLE is well researched across 3 clinical trials with over 350 patients
EQUELLE showed a significant reduction in hot flash frequency, and it was also shown to support sleep quality and vaginal health as well as alleviate mood swings1-3†
EQUELLE uses a nonhormonal compound to relieve menopause symptoms*†
Naturally derived‡ S-equol binds to estrogen receptors to mimic some but not all of the effects of estrogen by preferentially binding to ER-ß over ER-α without affecting sex and thyroid hormone concentrations.4,5
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