The safe, non-hormonal menopause symptom relief that women want.†*

Equelle's multi-symptom relief supplement is backed by decades of research that you & your patients can trust.1-3

All-in-one solution

A dietary supplement for multi-symptom menopause relief.

  • Fewer Hot
  • More
  • Alleviates
    Mood Swings
  • Reduces Vaginal
  • Relieves Muscle
  • Supports
    Healthy Bones

Trust & Safety

Backed by decades of research. 1-3

  • No modification

    to breast density
  • No changes

    in sex or thyroid hormone concentrations
  • No negative effects

    to endometrial health identified
“I confidently recommend Equelle to my patients seeking relief from menopausal symptoms. Its clinically studied ingredient offers a natural solution that many women find incredibly beneficial.”
Dr. James A. Simon
“I’ve been recommending Equelle to my patients for years. It improves sleep, with fewer hot flashes and less vaginal irritation.”
Nurse Barb Dehn
Women’s Health Nurse Practitioner
Certified Menopause Practitioner
"Equelle is safe and effective for addressing a wide range of menopausal symptoms, whether you’re still getting your period or haven’t had it in 20 years."
Dr. Kellogg-Spadt
"I am committed to conducting scientific research that helps women full stop! Navigating and managing symptoms associated with estrogen decline is hard; we believe that women need multiple tools in the tool box to help them on their menopause journey."
Dr. Susan Mitmesser
PhD Nutrition Biochemistry
"Each woman's menopause journey is so unique and I am grateful to provide support for these women as they navigate this important life change."
Heather Ott
Registered Dietitian Nutritionist (RDN)

What is in Equelle?

Powered by S-equol.

Beyond a soy isoflavone.

Harvested from soy germ, S-equol is a targeted isoflavone metabolite with decades of safety and efficacy research behind it.

S-equol is naturally produced by
the human gut when daidzein, a
soy isoflavone, is metabolized

Some women naturally
produce S-equol through soy

The only supplement that uses
S-equol to provide symptom
relief during menopause

Mechanism of Action

S-equol has unique binding properties.5

S-equol is structurally similar to estrogen allowing it to mimic some estrogenic effects for targeted relief.

S-equol preferentially binds to ER-β. Unlike ER-α, ER-β is rarely expressed in:

  • Mammary glands
  • Ovarian theca cells
  • Uterus

See how
Equelle works

From our community

Real reviews from real women.

Healthcare professionals trust Equelle to support their patients' menopause symptoms.

“Because of Equelle, I have no hot flashes or mood swings.”
Age 56
“It’s been a lifesaver for hot flashes and helps me sleep better as well.”
Age 57
“Reduces severity and duration of my nighttime hot flashes.”
Age 65
“Without Equelle I don't know how I would be handling this process in a woman's life. I'm so happy I found it!”
Age 50

Medical FAQs

  • Each tablet of Equelle contains 5mg of S-Equol and 120mg of Calcium.

  • It is recommended to take 10mg of Equelle daily, with or without food

  • No! Equelle is non-prescription, non-hormonal support for multi symptom menopause relief.

  • In clinical trials, Equelle provided menopause symptom relief as early as 1 month, with optimal results in 2-3 months.6-9

  • Equelle is available on subscription for $40/month or $50/month for a one-time purchase. Let us know if you would like samples and/or coupons for your patients at

  • Equelle is exclusively available through our website. Please encourage them to visit to learn more and buy Equelle today!

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