All-in-one natural menopause relief.

Equelle is the only supplement with S-equol, proven to address the root cause of menopause symptoms by naturally mimicking estrogen.

SHOP EQUELLE

All-in-one natural menopause relief.

Equelle is the only supplement with S-equol, proven to address the root cause of menopause symptoms by naturally mimicking estrogen.

SHOP EQUELLE

Plant-based and Powerful

Equelle is powered by S-equol — a plant-based ingredient that is clinically proven to relieve a range of menopause symptoms ¹

Fewer hot flashes

More sleep

Improves mood

Reduces vaginal symptoms

Alleviates muscle aches

How does Equelle work?

Traditional hormone replacement therapy replaces the estrogen that your body stops making during menopause. These hormones bind to estrogen receptors all over the body, including breast, ovarian, and uterine tissues.

Equelle's plant-based ingredient, S-equol, binds only to some estrogen receptors, relieving menopause symptoms while not effecting breast, ovarian, or uterine tissues.

20 years of clinical research for proven safety

Equelle's active ingredient, S-equol, is a plant-based compound clinically researched for decades, recognized as safe by the FDA, and proven safe with:

No association with breast cancer or other cancers
No changes in sex or thyroid hormones
No negative effects on endometrial health

VIEW PRODUCT

Results with the data to back them up

In randomized, placebo-controlled clinical trials, women taking Equelle experienced ¹ :

+50

more minutes of sleep ⁵

-5

fewer hot flashes per day ³

92%

satisfaction

SEE CLINICAL RESEARCH

Ready to get relief from your menopause symptoms?

ORDER EQUELLE

Brought to you by America's #1 Pharmacist Recommended Vitamin & Supplement Brand

Equelle is trusted by over 300,000 women and recommended by thousands of doctors in Japan. After 20 years of research, Equelle is being brought to the United States exclusively by the makers of Nature Made, the #1 Pharmacist Recommended Vitamin & Supplement Brand ² in America.

READ OUR STORY

You're not alone

See how Equelle is helping women like you relieve their menopause symptoms.

I've tried four different supplements as possible solutions to alleviate the horrible and disruptive hot flashes. I was suffering through 4-6 severe hot flashes every hour and I was miserable. Equelle helped lessen the severity and frequency of the flashes, I started feeling human again.

Joanne

I was a little hesitant to buy this. Hot flashes have been brutal, but this really works!!! A total game changer!! So grateful for a natural alternative to HRT!!! Will continue to buy this product!!!

Katie

Ladies it’s SO rare to find a product that actually works and does what it claims! Equelle has changed my mood in a completely noticeable way! For me, it took approximately 3 weeks to notice a real change. I now catch myself feeling really happy and a feeling of, for lack of better words, a feeling of well being!

Machelle

This product really works. I was having hot flashes several times a day, and after about 3 weeks of taking Equelle my hot flashes are minimum to none. I signed up for the membership and every month my subscription would arrive without worries.

Robin

Read All Reviews

Our refund policy

We know it’s important to try Equelle to make sure it works for you. Some women see relief in as early as 1 month, with optimal results in 2-3 months.

That's why we have a 90 day money-back guarantee. If Equelle doesn’t work for you, we’ll make it easy and refund you in full. Our team is here to help!

Real reviews from real women

This area allows women like you to express their own opinions and comments about Equelle. We stay out of it! These reviews are unfiltered and uncurated.