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† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

* Free from human or animal hormones. Contains trace amounts of plant isoflavones.
‡ Supports vascular health as you age
⁋ Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), which is a 19-item questionnaire designed to measures sleep disturbance. A higher score on the PSQI indicates greater sleep disturbances.
# Sleep minutes were calculated using the Motionlogger Micro Watch (a wearable sleep tracker) that patients wore at home for a week at a time to measure changes in sleep.
|| In a multicenter, double-blind, placebo-controlled trial, 118 perimenopausal or menopausal women were randomized to receive EQUELLE or placebo for up to 12 weeks.
§ Data on file. In-Home Usage Test. Pharmavite LLC.
1. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency.
2. Data on File. 1811 Study Report; Pharmavite LLC
3. Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M, Ishimi Y. Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized placebo-controlled trial. Menopause. 2011;18(5):563-574.
4. Aso T, Uchiyama S, Matsumura Y, er al. A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women. J Womens Health. 2012;21(1):92-100.
5. Ishiwata N, Melby MK, Mizuno S, Watanabe S. New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women. Menopause. 2009 Jan-Feb;16(1):141-8. doi: 10.1097/gme.0b013e31818379fa. PMID: 19131846.
6. Utian WH, Jones M, Setchell KDR. J Women’s Health (Larchmt). 2015;24(3):200-208. http://doi.org/1089/jwh.2014.5006.
7. Tempfer CB, Froese G,Heinze G, Bentz EK, Hefler LA, Huber JC. Side effects of phytoestrogens: a meta-analysis of randomized trials. Am J Med. 2009;122(10):939-46.e9, J Nutr. 2009;139(5):981-986.
8. Setchell KD, Clerici C. Equol: history, chemistry, and formation, J Nutr. 2010;140(7):1355S-62S
9. Muthyala RS, Ju YH, Sheng S, et al. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem. 2004;12(6):1559-1567.
10. Nilsson S, Gustafsson JÅ. Clin Pharmacol Ther. 2011;89(1):44-55.
11. Pearce ST, Jordan VC. Crit Rev Oncol Hematol. 2004;50(1):3-22.
12. Kauffman EC, et al. Oncol Rep. 2013;30(1):131-138. doi:10.3892/or.2013.2416.
13. Sen A, et al. Immunobiology. 2021;226(1):152020.
14. Usui, Takeshi, et al. “Effects of natural S‐equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status.” Clinical Endocrinology 78.3 (2013): 365-372.

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