How It Works

Naturally Derived. Proven by Science.

See how the menopause supplement from EQUELLE is changing the game with S-equol.

The shape of relief

S-equol bonding with estrogen

During the menopause transition, estrogen production begins to fluctuate and ultimately decreases. Decreased production of estrogen can cause disruptive symptoms such as hot flashes.

S-equol, a plant-based compound and EQUELLE’s active ingredient, shares a similar structure to estrogen and binds to estrogen receptors in the body. With this bond, S-equol helps alleviate hot flashes and muscle aches associated with menopause.

S-equol bonding with estrogen

Get real relief

Real menopause relief is hard to find. But through decades of research, we found it at work in nature. Taking our findings, we developed a proprietary process to deliver clinically shown relief from common menopause symptoms. EQUELLE is now trusted by tens of thousands of women for menopause relief.

Discovered in some. Developed for all.

Estrogen and S-Equol

Ever wonder why some women have fewer menopause symptoms like hot flashes? One reason could be that their bodies naturally produce S-equol—the active ingredient in EQUELLE.

Over years of research, it was discovered that S-equol is structurally similar to, and mimics some of the actions of estrogen, helping to reduce hot flashes and muscle aches. †

We recreated this natural compound so that more women can experience its benefits.

Estrogen and S-Equol

In her Words

“I was plagued with hot flashes every hour during the day. After taking EQUELLE..., my symptoms came almost to a stop. Best thing I ever tried.”

“EQUELLE made an enormous difference in the quality of my life! It reduced the frequency...of my hot flashes so that I was able to work, play, and sleep.”

“It really helped.”

“What a difference it made!! This is a true GODSEND!"

“It helped a lot with the unpleasant symptoms of menopause.”