more minutes of sleep per night 5


fewer hot flashes per day 3


vaginal symptoms 4


overall mood 5

How long will it take to feel the effects of Equelle?

In clinical trials, Equelle provided menopause symptom relief as early as month 1, with optimal results in 2-3 months. That's why we offer a 90 day money-back guarantee. Because S-equol works by safely mimicking estrogen in the body, it takes time to reach optimum results. The results on Equelle have been separately validated in 4 randomized, placebo-controlled clinical trials.

Your journey might be different than others, but this is a look at what other women experienced in clinical trials:

  • The journey to symptom relief begins.

  • Women with frequent hot flashes reported daily hot flash relief and improvements in sleep quality in poor sleepers.
  • Women reported an average of 5 fewer hot flashes per day and experience a significant decrease in irritability.
  • Women reported an average of 50 minutes more sleep per night, improved vaginal symptoms like irritation, itching, and soreness, and significant improvements in overall mood.
  • After 12 weeks, 92% of women reported they were satisfied with Equelle.

See the Clinical Research for yourself

As published in the Journal of Women's Health

A Natural S-equol Supplement Alleviates Hot Flushes and Other Menopausal Symptoms in Equol Nonproducing Postmenopausal Women

As published in menopause, the journal of the North American Menopause Society

New Equol Supplement for Relieving Menopausal Symptoms: Randomized, Placebo-controlled Trial of Women

As published in Journal of Women's Health

A Pilot Study on the Effects of S-equol Compared to Soy Isoflavones on Menopausal Hot Flash Frequency

A collection of publications on the clinical research and development of s-equol

A collection of 16 research reports and clinical trials on S-equol’s development and menopause symptom relief benefits from 2007 to 2014

20 years of dedicated research.

Ready to get relief from your menopause symptoms?