Frequently Asked Questions

Key Ingredient: S-equol 

Inactive Ingredients: Calcium, Dicalcium Phosphate, Fermented Soy Germ, Silicon Dioxide, Croscarmellose Sodium, Magnesium Stearate, Coating (Hypromellose, Glycerin, Hydroxypropyl Cellulose), Microcrystalline Cellulose. Contains Soy*

*The soy used to derive S-Equol in Equelle’s proprietary process has been tested and is certified as non-GMO.

S-equol, the key ingredient in Equelle, is a plant-based, non-hormonal compound. It is produced through our patented soy germ fermentation process. 

This process starts by extracting a small amount of soy germ from the bean, which is then added to the fermentation conditions and produces S-equol. Only small traces of soy compounds remain in the final Equelle product. 

1 in 5 American women are able to produce S-equol in their own bodies after eating soy. Researchers have found that these women experience more mild menopause symptoms as a result. However, they are unable to produce enough S-equol to fully alleviate menopause symptoms and can still benefit from Equelle.

The soy used to derive S-Equol in Equelle’s proprietary process has been tested and is certified as non-GMO.

Equelle is a hormone-free, non-prescription dietary supplement with naturally-derived S-equol. Equelle provides symptom relief due to estrogen decline by helping to reduce the frequency of hot flashes, supporting sleep quality, reducing vaginal irritation, alleviating mood swings and decreasing muscle aches.

Equelle's active ingredient, S-equol, works by safely and naturally mimicking estrogen. As estrogen declines, menopause symptoms go up. S-equol acts like estrogen in your body to help decrease menopause symptoms ¹

Equelle has been clinically validated to alleviate symptoms, such as reducing the frequency of hot flashes, supporting sleep quality, alleviating mood swings, alleviating muscle aches and reducing bothersome vaginal symptoms such as irritation, soreness and itching. In clinical studies, participants taking Equelle experienced reduced hot flash frequency starting as early as one month, with about 5 fewer hot flashes per day at week 8 compared to baseline. After 3 months of taking Equelle participants slept 50 minutes more on an average per night vs. 16 minutes more with placebo.

You can take Equelle if you are in perimenopause, menopause, or postmenopause. If you're experiencing symptoms like hot flashes, sleep disturbances, vaginal discomfort, and more, Equelle may be right for you.

Equelle is the only supplement with S-equol, which naturally mimics estrogen to alleviate symptoms due to estrogen decline. Equelle is built on 20 years of research and development, uses a patented production process and has conducted 4 randomized, placebo-controlled clinical trials. 

Taking Equelle does not impact estrogen levels. Although Equelle’s active ingredient, S-equol, mimics some of the same activities of estrogen by preferentially binding to estrogen receptor beta, Equelle is a dietary supplement free from human & animal hormones and clinical research shows S-equol supplementation reduces the frequency of hot flashes, supports the quality of sleep, reduces bothersome vaginal symptoms like irritation, soreness and itching, and alleviates mood swings¹

Your body has two main types of estrogen receptors, called alpha receptors and beta receptors. Alpha receptors are primarily in your breast, ovarian, and uterine tissues. Beta receptors are primarily in places like the lining of your blood vessels and some parts of your brain. Estrogen, and estrogen hormone replacement therapies, bind to both alpha and beta receptors. S-equol has a similar molecular structure to estrogen but mostly binds to beta receptors.

By favoring these beta receptors, S-equol:

• Mimics the benefits of estrogen and relieves symptoms
• Does not increase your risk for breast cancer and is not associated with changes in sex or thyroid hormones or endometrial health

S-equol, the key ingredient in Equelle, is a plant-based, non-hormonal compound. It is produced through our patented soy germ fermentation process.

This process starts by extracting a small amount of soy germ from the bean, which is then added to the fermentation conditions and produces S-equol. Only small traces of soy compounds remain in the final Equelle product.

1 in 5 American women are able to produce S-equol in their own bodies after eating soy. Researchers have found that these women experience more mild menopause symptoms as a result. However, they are unable to produce enough S-equol to fully alleviate menopause symptoms and can still benefit from Equelle.

Equelle's active ingredient, S-equol, comes from Japan. It is tableted and manufactured in the United States. 

Your doctor may be able to provide you with samples of Equelle. However, samples are not available in all areas. If you are unable to receive samples, we do offer a 90-day money-back guarantee so it's risk-free to try!

Take 1 tablet of Equelle in the morning, and 1 tablet at night. This will maintain sufficient levels of S-equol in your body to help you with your symptoms throughout the day— morning and night.

Equelle should be taken as long as your symptoms persist. Menopause symptoms are caused by declining estrogen and you can experience these symptoms for several years, until the body adjusts to those declining levels. Equelle can help relieve these symptoms during this time. If you feel like your symptoms have subsided, you can try to stop taking Equelle and see if your symptoms return. Equelle has been extensively studied and there are no safety issues with taking Equelle for a long period of time.

Yes, Equelle can be broken or crushed and taken in liquid or food.

You do not have to take Equelle with food. However, if you tend to have a sensitive stomach, we recommend taking Equelle with food to help minimize any potential discomfort. 

In clinical trials, Equelle provided menopause symptom relief as early as 1 month, with optimal results in 2-3 months. Participants receiving Equelle experienced about 5 fewer hot flashes per day at 2 months compared to baseline. After 3 months of taking Equelle participants slept 50 minutes more on an average per night vs. 16 minutes more with placebo. After 3 months, 92% of participants in an online survey reported they were satisfied with Equelle.

Equelle and its active ingredient, S-equol, have undergone decades of clinical research and development. The active ingredient in Equelle, S-equol, is Generally Recognized as Safe (GRAS) for use in dietary supplements. It has been shown to be safe and is not associated with changes in sex or thyroid hormones, negative effects on endometrial health or breast cancer. Some individuals have reported gastrointestinal side effects and they can subside after a few days to a week of taking the product. It can also help to take Equelle with food. If you are experiencing any adverse effects, we recommend discontinuing product use and consulting your physician or healthcare professional.

Yes, three double-blind, randomized clinical trials were conducted. The results support relief from the common symptoms associated with menopause including reducing frequency of hot flashes and vaginal irritation, alleviating mood swings, and supporting quality of sleep. Read our studies here. In addition, Equelle and its active ingredient S-equol have gone through decades of research, development, and multiple clinical studies to determine the safety of the ingredient.

Equelle should not be taken if you have a soy allergy or soy sensitivity. The key ingredient in Equelle, S-Equol, does not have any known interactions with medications or supplements in a clinical setting.

Equelle’s formulation contains calcium, which is recommended to be taken separately from both iron and thyroid medications for proper absorption. For specific guidance, we recommend the following:

Iron Supplements and/or Multivitamins Containing Iron: take 1-2 hours apart from Equelle.

Thyroid Medication: take Equelle 4 hours apart from your thyroid medication. We always recommend you discuss any supplement use with your doctor.

Yes, if you are experiencing symptoms due to entering menopause naturally or through induced menopause, consider Equelle to alleviate some of your symptoms like frequency of hot flashes, mood swings, vaginal irritation, and to support sleep quality.

We always recommend consulting with your healthcare professional to ensure you are making the best decision for your body and needs as this is a deeply personal issue. However, Equelle has been clinically studied and shown to be safe.

Your body has two main types of estrogen receptors, alpha receptors and beta receptors. Alpha receptors are primarily in your breast, ovarian, and uterine tissues. Beta receptors are primarily in places like the lining of your blood vessels and some parts of your brain. Estrogen, and estrogen hormone replacement therapies, bind to both alpha and beta receptors. S-equol has a similar molecular structure to estrogen but mostly binds to beta receptors.

By favoring these beta receptors, S-equol:

• Mimics the benefits of estrogen and relieves menopause symptoms
• Does not increase your risk for breast cancer and is not associated with changes in sex or thyroid hormones or endometrial health

S-equol is derived from soy using a patented process. A report for the American Institute for Cancer Research notes that a moderate amount of soy (1 to 2 servings a day) is considered safe for survivors and may even be beneficial. Only trace amounts of soy compounds remain in the final Equelle product.

Only trace amounts of soy compounds remain in the final Equelle product. These amounts are significantly less than those present in a single serving of most common soy foods.

Equelle is a dietary supplement regulated by the FDA and we adhere to FDA regulations that require us to follow Current Good Manufacturing Practices (CGMP). The active ingredient in Equelle, S-equol, is Generally Recognized as Safe (GRAS) for use in dietary supplements.

No. During our fermentation process, only small trace amounts of soy compounds remain in the final Equelle product. These amounts are significantly less than those present in a single serving of most common soy foods. However, since there are still small trace amounts of soy compounds, Equelle should not be taken if you have a soy allergy or sensitivity.

We aim to make it easy to stay on top of your symptoms due to estrogen decline. So you never miss a dose, each month we will send you a monthly supply, and bill your payment method on file. You will always receive an email 3 days prior to your order renewing, in case you need to make any updates before your order ships. 

To access your subscription portal, please follow the prompts here.  If you are having issues accessing your account please email us at hello@equelle.com and we'll be happy to help! 

First login to your account here. Once you are logged into your account, scroll to the bottom of the page to the section labeled 'Payment Method'. Click on the box and update the payment. Once you've entered your new card details, click the blue 'Add Payment Method' button to save any changes.

First login to your account here. Once you are logged into your account, scroll to the section labeled 'Shipping Address'. Click the green 'Edit' button and enter your new shipping address. To save your changes, scroll to the bottom and click the green 'Update Shipping Address' button.

If you are a subscriber login to your account here. Scroll to the bottom of the page and click the 'View Purchase History' button. From there, you'll be able to access the details of your past orders.

If you've only made a one-time purchase and need your order history, please email us a hello@equelle.com and we'll be happy to assist you! 

First login to your account here. Once you are logged into your account, scroll to the section labeled 'Next Charge Date'. Here, you'll have the option to delay 2 weeks, delay 4 weeks or choose a next charge date.

Login to your account here. Scroll to the bottom of the page and click the 'Cancel' button. From there, you'll need to choose an option from the list and confirm your cancelation.

Absolutely! In addition to our subscription plan, we also offer a one-time purchase option here.  

Yes, in the United States, shipping is always free!

No, we do not ship internationally at this time.

Fulfillment is typically 1-2 business days after your order is placed and shipping takes approximately 3-5 business days. Once your order has shipped, you will receive an email with tracking information.

We want you to be happy with Equelle. We offer a 90-day money-back guarantee. Simply email us at hello@equelle.com and we will take care of you.

Equelle is currently offered online through our website and is not available in stores at this time.