Frequently Asked Questions

Key Ingredient: S-equol 

Inactive Ingredients: Dicalcium Phosphate, Fermented Soy Germ, Silicon Dioxide, Croscarmellose Sodium, Magnesium Stearate, Coating (Hypromellose, Glycerin, Hydroxypropyl Cellulose), Microcrystalline Cellulose. Contains Soy*

*The soy used to derive S-Equol in Equelle’s proprietary process has been tested and is certified as non-GMO.

S-equol, the key ingredient in Equelle, is a plant-based, hormone-free* compound. It is a plant-based compound produced through the fermentation of soy germ and is naturally produced by some women in the gut in small amounts after consuming soy.

The soy used to derive S-Equol in Equelle’s proprietary process has been tested and is certified as non-GMO.

Equelle is a hormone-free*, non-prescription dietary supplement with naturally-derived S-equol. Equelle provides symptom relief due to estrogen decline by mimicking some of the beneficial effects of estrogen in the body. Equelle has been studied to help reduce the frequency of hot flashes and muscle aches. Equelle also supports sleep quality and healthy bones.

Equelle's active ingredient, S-equol, works by safely and naturally mimicking estrogen. As estrogen declines, menopause symptoms go up. S-equol acts like estrogen in your body to help decrease menopause symptoms ¹

Equelle has been clinically studied to alleviate symptoms, such as reducing the frequency of hot flashes and alleviate muscle aches. Equelle also supports sleep quality and healthy bones. 

You can take Equelle if you are in menopause or post menopause. If you're experiencing symptoms associated with estrogen decline, such as hot flashes, muscle aches and more, Equelle may be right for you.

Equelle is a supplement with naturally derived S-equol, which naturally mimics estrogen to alleviate symptoms due to estrogen decline. Equelle is built on decades of research and development on S-Equol, uses a patented production process and has conducted 4 randomized, placebo-controlled clinical trials.

Taking Equelle does not impact estrogen levels. Although Equelle’s active ingredient, S-equol, mimics some of the same activities of estrogen by preferentially binding to estrogen receptor beta, Equelle is a dietary supplement free from human & animal hormones. Clinical research shows S-equol supplementation reduces the frequency of hot flashes, muscle aches, and more. Equelle also helps support sleep and healthy bones. 1

Your body has two main types of estrogen receptors, called alpha receptors and beta receptors. Alpha receptors are primarily in your breast, ovarian, and uterine tissues. Beta receptors are primarily in places like the lining of your blood vessels and some parts of your brain. Estrogen, and estrogen hormone replacement therapies, bind to both alpha and beta receptors. S-equol has a similar molecular structure to estrogen but primarily binds to beta receptors.

By favoring these beta receptors, S-equol:

• Mimics the benefits of estrogen and relieves symptoms
• Has not been associated with an increased risk for breast cancer and is not associated with changes in sex or thyroid hormones or endometrial health

S-equol, the key ingredient in Equelle, is a plant-based, hormone-free* compound. It is produced through our patented soy germ fermentation process.

This process starts by extracting a small amount of soy germ from the bean, which is then added to the fermentation conditions and produces S-equol. Only small traces of soy compounds remain in the final Equelle product.

1 in 5 American women are able to produce S-equol in their own bodies after eating soy. Researchers have found that these women experience more mild menopause symptoms as a result. However, they are unable to produce enough S-equol to fully alleviate menopause symptoms and can still benefit from Equelle.

Equelle's active ingredient, S-equol, comes from Japan. It is tableted and manufactured in the United States. 

Your doctor may be able to provide you with samples of Equelle. However, samples are not available in all areas. If you are unable to receive samples, we do offer a 90-day money-back guarantee, we'll make it easy and refund up to 3 bottles if Equelle doesn't work for you!

Take 2 tablets daily. This will help maintain sufficient levels of S-equol, giving you relief during the day and night. We recommend taking with food if you tend to have a sensitive stomach when taking supplements.

Equelle should be taken as long as your symptoms persist. Menopause symptoms are caused by declining estrogen and you can experience these symptoms for several years, until the body adjusts to those declining levels. Equelle can help relieve these symptoms during this time. If you feel like your symptoms have subsided, you can try to stop taking Equelle and see if your symptoms return. Equelle has been extensively studied and there are no known side effects of taking Equelle long term.

Yes, Equelle can be broken or crushed and taken in liquid or food.

You do not have to take Equelle with food. However, if you tend to have a sensitive stomach, we recommend taking Equelle with food to help minimize any potential discomfort. 

What time of day you take Equelle is not as important as ensuring you are getting 10 mg of S-Equol (that's 2 tablets) daily. This said, you may prefer to take Equelle to align with when you experience the most symptoms (ie: take in the PM before bed if you experience the majority of symptoms at night).

In clinical trials, Equelle provided menopause symptom relief as early as 1 month, with optimal results in 2-3 months. 

Equelle’s key ingredient, S-equol, has undergone decades of clinical research and development. It has been studied to be safe and to have no changes on sex or thyroid hormone levels, negative effects on endometrial health, and no association with breast cancer.

In general, taking botanicals or plant-based supplements may result in possible gastrointestinal upset. We recommend taking Equelle with food if you experience stomach sensitivity with supplements.

If you are experiencing any other adverse effects, we recommend discontinuing product use and consulting your physician or healthcare professional.

Yes, three double-blind, randomized clinical trials were conducted. The results support relief from the common symptoms associated with menopause including reducing frequency of hot flashes and supporting quality of sleep. Read our studies here. In addition, Equelle and its active ingredient S-equol have gone through decades of research, development, and multiple clinical studies to determine the safety of the ingredient.

Equelle’s formulation contains calcium, which is recommended to be taken separately from both iron and thyroid medications for proper absorption. For specific guidance, we recommend the following:

Iron Supplements and/or Multivitamins Containing Iron: take 1-2 hours apart from Equelle.

Thyroid Medication: take Equelle 4 hours apart from your thyroid medication. We always recommend you discuss any supplement use with your doctor.

We recommend speaking with your physician about using Equelle, with their expertise they will be able to tell you what is best for your specific situation.

Only a small amount of soy is in Equelle. This amount is significantly less than the amount in a single serving of common soy foods.

Equelle is a dietary supplement regulated by the FDA and we adhere to FDA regulations that require us to follow Current Good Manufacturing Practices (CGMP). The active ingredient in Equelle, S-equol has been safely studied in clinical trials.

No. During our fermentation process, only small trace amounts of soy compounds remain in the final Equelle product. These amounts are significantly less than those present in a single serving of most common soy foods. However, since there are still small trace amounts of soy compounds, Equelle should not be taken if you have a soy allergy or sensitivity.

We aim to make it easy to stay on top of your symptoms! To help ensure you never miss a dose and provide the best value, we offer discounted auto-renewal orders for either a 30-day supply billed every 4 weeks or 90-day supply billed every 12 weeks. We charge your payment method on file and you will always receive an email 3 days prior to your order renewing, in case you need to make any updates before your order ships. You can always change your renewal date or cancel your subscription at anytime in your subscription portal.

We also offer one-time purchases for individuals who prefer to order Equelle one order at a time.

To access your subscription portal, please follow the prompts here.  If you are having issues accessing your account please email us at hello@equelle.com and we'll be happy to help! 

First login to your account here. Once you are logged into your account, click on the ‘Address & payment details’ tab on the righthand side. Scroll to the bottom and click ‘Manage payment methods’. Click ‘Edit’ to the right of the payment method and click ‘Send edit payment link’ on the popup. This will then email you with a link to enter your new payment method. Once you enter it and save, it will automatically update in your account for future payments. 

First login to your account here. Once you are logged into your account, click on the ‘Address & payment details’ tab on the righthand side. Scroll to the middle and click ‘Manage addresses’. Click ‘Edit’ to the right of your address and enter your new address details. Once you enter your new address and save, it will automatically update in your account for future orders. 

If you are a subscriber login to your account here. Click 'View previous orders' on the righthand side. From there, you'll be able to access the details of your past orders.

If you've only made a one-time purchase and need your order history, please email us at hellp@equelle.com and we'll be happy to assist you!

First login to your account here. Once you are logged into your account, select "View your next order" on the righthand side. From there, you will need to select "reschedule" next to the calendar icon. A pop up will allow you to select to delay your order 1 week, 2 weeks, or choose a specific date of your choosing.

Login to your account here. Under your subscription, click the option to ‘Manage this subscription’. At the bottom of the page, click ‘Cancel subscription’. From there, you'll need to choose an option from the list and confirm your cancellation. You must cancel your order before your next subscription renewal order is processed in order to avoid future charges. 

Absolutely! In addition to our subscription plan, we also offer a one-time purchase option here.  

Yes, in the United States, shipping is always free!

No, we do not ship internationally at this time.

Fulfillment is typically 1-2 business days after your order is placed and shipping takes approximately 3-6 business days. Once your order has shipped, you will receive an email with tracking information.

While we don't accept returns, we want you to be happy with Equelle. If Equelle doesn't work for you, we'll make it easy and refund you in full. Our 90-day money-back guarantee covers up to 3 bottles if you have not found relief by the end of your third month. Simply email us at hello@equelle.com and we will take care of you.

Our 90-day Money Back Guarantee is designed to give you the opportunity to try Equelle risk-free, as results may take up to 2-3 months to notice. If you haven’t found relief by the end of your third month with Equelle, you can request a full refund for up to three bottles.

To take advantage of this guarantee, simply email our customer support team at hello@equelle.com within 120 days of your purchase date. We’re here to help!

Equelle is currently offered online through our website and is not available in stores at this time.

Orders are occasionally marked as delivered before the arrival date. If your order has not arrived within 72 hours from time of marked delivery, please reach out to our customer support team at hello@equelle.com and we would be happy to assist.

Please send us a photo of the damage to our customer support team at hello@equelle.com. Our team would be happy to take care of you!