First demonstration that S-equol can be used in estrogen-mediated conditions.
Soy flour consumption linked to menopause symptom reduction.
Lactic acid bacteria that produces S-equol identified in fermented soybean germ
Higher S-equol production linked to reduced menopause symptoms.
Double-blind trials to assess efficacy and safety among women taking S-equol were completed.
Equelle launches in Japan
Equelle launches in U.S.
Clinical trial assessing multiple menopausal symptoms including sleep, mood, and vaginal health in a U.S. population
Clinical results presented at North American Menopause Society Annual Meeting showing the first efficacy data on sleep and vaginal symptoms
Proudly bringing you Equelle
From America's #1 Pharmacist Recommended Vitamin & Supplement Brand 2
That’s why we’re proud to exclusively offer S-equol, a plant-based ingredient backed by decades of efficacy and safety research, with Equelle. Equelle uses the same powerful plant-based ingredient that’s giving menopause relief to so many women in Japan with the quality and dedication to science you trust with Nature Made.
S-equol — from chance discovery to menopause relief
Using a patented fermentation process, S-equol is produced from soybeans. Over time, numerous clinical trials were conducted to assess efficacy and safety among women taking S-equol, and when successful, in 2014 Equelle was launched in Japan. Since launch in Japan, Equelle has become the most popular non-prescription menopause solution among Japanese women and health care practitioners.
Decades worth of research
Meet the Equelle Team of Medical Advisors
Barb Dehn, NP
Barbara Dehn RN, MS, NP is a practicing Women’s Health Nurse Practitioner. She is certified by the North American Menopause Society and is the award winning author of the Personal Guides to Health used by over 5 million women in the US, with titles ranging from fertility and pregnancy to menopause and breastfeeding. She is also the award winning author of The Hot Guide to a Cool Sexy Menopause and amplifies women’s health education through her broad reach.
Tomomi Ueno, MS
Tomomi Ueno is a plant chemist and
has been researching soy isoflavones and equol to promote women’s health for 26 years at the Saga Nutraceuticals Research Institute at Otsuka Pharmaceutical in Japan. Ms. Ueno has been influential in the research and development behind Equelle and was a part of the team that brought Equelle to market. Ms. Ueno earned her Master’s degree in Plant Physiology in the Graduate School of Science from Kumamoto University.
Michael L. Krychman, MD
Michael L. Krychman, MD, is the Executive Director of the Southern California Center for Sexual Health and Survivorship Medicine located in Newport Beach California. He is an active member of the North American Menopause (NAMS) and Board certified Obstetricians and Gynecologists. He is also a clinical sexologist, sexual counselor and has completed his Masters in Public Health and Human Sexuality. His special interests include menopausal health, hormone therapy, sexual pain disorders, loss of libido, chronic medical illness and medical devices and their impact on female sexual function.
Dr. Susan Mitmesser, PhD Nutrition Biochemistry
Susan is Vice President of Science & Technology at Pharmavite, the makers of Nature Made. As a leading biochemist, Dr. Mitmesser specializes in analyzing the scientific integrity of the ingredients to ensure optimum product function and efficacy. With her research, she helps drive long term, innovative solutions in women’s health including in the field of menopause. Pharmavite is the maker of the leading vitamin and supplement brand, Nature Made. Equelle is a part of Pharmavite's women's health division. She holds a PhD in Nutrition Biochemistry from the University of Nebraska and a Master’s degree from the University of Nebraska Medical Center.
Shigeto Uchiyama, Pharmacist
Shigeto Uchiyama is a pharmacist specializing in women's health care certificated by the Japan Society for Menopause and Women's Health. Mr. Uchiyama has been researching soy isoflavones and Equol since 1996 at the Saga Nutraceuticals Research Institute at Otsuka Pharmaceutical in Japan. Mr. Uchiyama was a part of the team that developed Equelle and has been a key contributor to the research and development behind Equelle. Mr. Uchiyama earned his Master’s degree in Pharmaceutical Sciences in the Graduate School of Science from Kumamoto University.