$45.95 /month


$45.95 /month
Powered by nature. Proven by science.
Non-prescription, dietary supplement with naturally derived S-equol.* EQUELLE has been clinically validated to alleviate menopause symptoms:
  • Reduces the frequency of hot flashes
  • Supports quality of sleep
  • Alleviates mood swings
  • Reduces vaginal irritation, soreness, and itching†§
Subscribe for $39.95
INGREDIENTS: Fermented Soy Germ, Cellulose Gel, Calcium Phosphate, Stearic Acid, Sorbitol, Silicon Dioxide, Sodium Silcate, Croscamellose Sodium, Organic Coating (Tapioca Maltodextrin, Sunflower Lecithin, Palm Oil, Guar Gum).
Suggested use:

Take 2 tablets twice daily with water. Take 2 tablets in the morning and 2 tablets in the evening.

This will maintain sufficient levels of S-equol in your body to help you with your symptoms throughout the day— morning and night.

How does EQUELLE work?

During menopause, estrogen levels decrease causing symptoms like hot flashes, sleep difficulties and vaginal irritation. EQUELLE's active ingredient, S-equol, has a similar structure as estrogen and can mimic some of its actions, helping to ease menopause symptoms.

How quickly can I expect results?

In clinical trials, EQUELLE provided daily hot flash frequency relief as early as week 4, with optimal results in 8-12 weeks. Participants receiving EQUELLE experienced about 5 fewer hot flashes per day at week 8 compared to baseline. After 12 weeks of taking EQUELLE participants slept 50 minutes more on average per night vs. 16 minutes more with placebo. After 12 weeks, 92% of participants in an online survey reported they were satisfied with EQUELLE.

Is EQUELLE safe to take? Are there side effects?

EQUELLE and its active ingredient, S-equol, have undergone decades of clinical research and development. It has been shown to be safe and is not associated with changes in sex or thyroid hormones, negative effects on endometrial health or breast cancer.1-4 In general, taking botanicals or plant-based supplements may result in possible gastrointestinal upset. If you are experiencing any adverse effects, we recommend discontinuing product use and consulting your physician or healthcare professional.

Does EQUELLE increase estrogen levels?

Taking EQUELLE does not impact estrogen levels. Although EQUELLE’s active ingredient, S-equol, mimics some of the same activities of estrogen by preferentially binding to estrogen receptor beta, EQUELLE is a hormone free dietary supplement and clinical research shows S-equol supplementation reduces the frequency of hot flashes, supports the quality of sleep, alleviates mood swings, and reduces bothersome vaginal symptoms like irritation, soreness and itching.

How much soy does EQUELLE contain?

Only the smallest amount of soy compounds exist in EQUELLE and it is significantly less than what you’d find in a single serving of most common soy foods.

How is EQUELLE different than other supplements?

EQUELLE is a supplement that contains a standardized amount of its active ingredient, S-equol, in every tablet. Many other supplements for menopause are herbal supplements. The growing conditions and potency of herbs (such as black cohosh or evening primrose oil) may be varied and inconsistent, which may impact their effectiveness.


In their own words...

“EQUELLE made an enormous difference in the quality of my life! It reduced the frequency...of my hot flashes so that I was able to work, play, and sleep.”

"I took it in the morning and I took it at night, and it was easy to remember, and it really helped."

"After 6 weeks of taking EQUELLE, I really felt like a much better version of myself."

Real reviews from real women

Hundreds of thousands of women trust EQUELLE for menopause symptom relief.†

*These users received free product

EQUELLE comes with a 60-day money back guarantee, because our commitment to science, substance, and quality is just as strong as our commitment to you.

Details 🡪


1. Tempter CB, Froese G, Heinze G, Bentz EK, Hefler LA, Huber JC. Side effects of hytoestrogens: a meta-analysis of randomized trials. Am J Med. 2009;122(10}:939-46.e9.
2. Maskarinec G, Verheus M, Steinberg FM, et al. Various doses of soy isoflavones do not modify mammographic density in postmenopausal women. J Nutr. 09;139(5):981-986.
3. Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M, lshimi Y. Natural S-equol decreases bone resorption in postmenopausal, non-equal-producing Japanese women: a pilot randomized, placebo-controlled trial. Menopause. 2011;18(5}:563-574.
4. Data on File. Global Data 2015; Pharmavite LLC.