Estrogen Decline Affects More than You Think

During menopause, it’s common for women to notice a range of changes within their body.

Women can experience hot flashes, muscle aches, mood swings, vaginal symptoms, and sleep disruptions.

Discover how Equelle, a multi-symptom menopause relief supplement with S-equol, is shown to naturally address the root cause of symptoms related to estrogen decline.

What happens during Menopause?

Before, during, and after menopause, the hormones that are responsible for controlling a woman’s menstrual cycle and reproductive health–estrogen and progesterone–are produced less and less 9.

This change is what leads to the telltale symptoms of menopause: the end of a woman’s menstrual cycle, as well as a number of other physical changes to the body.

It is important to note that the hormonal changes and symptoms that happen during menopause are the result of the body naturally changing over time and reaching a new status quo. Thus, the term ‘imbalance’ is not meant to imply any wrongdoing or ‘problem’ - it’s an acknowledgement of a natural and expected stage of life.

Discover Equelle

An estrogen decline symptom relief supplement with S-equol, a plant-based ingredient derived from soy that safely and naturally mimics estrogen - relieving hot flashes, improving sleep, and more.

How S-Equol Helps Alleviate Menopause Symptoms

S-equol is a non-hormonal compound derived from soy isoflavones. It's naturally derived from daidzein, a soy isoflavone.

In recent years, S-equol has gained popularity as an option for alleviating menopause symptoms.

Two milestone studies show the perks of this soy isoflavone for women undergoing menopause. The first study included 160 Japanese women, none of whom produced S-equol and had them either take 10mg of s-equol, or a placebo pill. Researchers discovered significant positive effects in the group taking s-equol in hot flash reduction and muscle stiffness decreases4.

In a U.S. study of 102 menopausal women, participants who took S-equol had relief from joint and muscle pain and saw a reduction in hot flash frequency1.

These studies both suggest that the power of S-equol is promising, especially for women who can’t fully reap the benefits of consuming soy isoflavones on their own 1,4.

Supplements containing S-equol can help mimic some of the beneficial effects of estrogen to alleviate symptoms like hot flashes. Many women find that non-hormonal and low-risk solutions like these are a great option for keeping unwanted symptoms at bay.

Try Equelle Today with our Money Back Guarantee.

We’re committed to helping you find relief – every step of the way. If Equelle doesn’t work for you, we’ll make it easy and refund you in full with our 90 day money-back guarantee.


1. Jenks, B.H. et al. (2012). A Pilot Study on the Effects of S-Equol Compared to Soy Isoflavones on Menopausal Hot Flash Frequency. Journal of Women's Health, p. 674-682.

4. Aso T, Uchiyama S, Matsumura Y, Taguchi M, Nozaki M, Takamatsu K, Ishizuka B, Kubota T, Mizunuma H, Ohta H. A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women. J Womens Health (Larchmt). 2012 Jan;21(1):92-100. doi: 10.1089/jwh.2011.2753. Epub 2011 Oct 12. PMID: 21992596.

9. “Menopause: Age, Stages, Signs, Symptoms & Treatment.” Cleveland Clinic. Accessed October 25, 2022.