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† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

* Contains plant isoflavones.
⁋ Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI).
|| Significant vs. baseline and not placebo.
1. Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency. J Womens Health (Larchmt). 2012;21(6):674-682. doi:10.1089/jwh.2011.3153
2. Data on File. 1811 Study Report; Pharmavite LLC
3. Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M, Ishimi Y. Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized placebo-controlled trial. Menopause. 2011;18(5):563-574.
4. Aso T, Uchiyama S, Matsumura Y, et al. A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women. J Womens Health. 2012;21(1):92-100.
5. National Institutes of Health, Office of Dietary Supplements. Calcium: Fact Sheet for Health Professionals. 2024. https://ods.od.nih.gov/factsheets/Calcium-HealthProfessional
6. Utian WH, Jones M, Setchell KDR. J Women’s Health (Larchmt). 2015;24(3):200-208. http://doi.org/1089/jwh.2014.5006.
7. Utian, W, LeeCole L, Mitmesser SH. S-equol improves quality of life for peri-and menopausal women with high vasomotor symptoms. Poster presentation at the NAMS 2021 conference; September 2021. Washington, DC. Abstract published in Menopause. 2021;28(12):P-68.

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