Hormone-free EQUELLE with plant-based S-equol helps reduce hot flashes and muscle aches associated with menopause.^‡

• No major events were reported in clinical studies
• No increase in breast density or endometrial thickness in post-menopausal women (10 or 30mg/day for 12 weeks)⁴

In a clinical study, women taking a daily oral dose of EQUELLE (containing 10mg S-equol per dose) reduced their frequency of hot flashes by 58.7% after 12 weeks of treatment (n=77), significantly (p<0.01) more than the 34.5% reduction experienced in women receiving a placebo (n=83).¹

S-equol is a metabolite of the soy isoflavone daidzein. S-equol is produced by intestinal bacteria in some, but not in all, humans after soy consumption. The ability of S-equol to play a role in the treatment of estrogen-mediated conditions was first proposed in 1984.⁶ Studies of postmenopausal women documented that those women who can produce equol after consuming soy had milder menopause symptoms than those who were unable to produce equol.^7,8 S-equol is exclusively a product of the bacterial transformation of daidzein. The molecular and physical structure of S-equol is similar to that of 17-estradiol,⁹ also referred to as estrogen, and mimics some, but not all, estrogenic activities.

As EQUELLE contains a soy-based ingredient, individuals who are allergic to soy should not take this product. In addition, women who are pregnant, nursing or trying to become pregnant should not use EQUELLE as the product has not been tested in these groups.

No major side effects have been reported in those using EQUELLE, however, there have been occasional reports of gas and bloating.

The recommended dose of EQUELLE is 10 mg, taken as two (2) tablets, twice a day, for a total of four (4) tablets/day.

You do not need a prescription for EQUELLE, however, patients should consult with their physician or healthcare professional before taking EQUELLE, especially if they are already taking medications or other supplements.