Introducing EQUELLE®

Clinically shown to help reduce the frequency of hot flashes and muscle discomfort associated with menopause.

  • Non-Hormonal
  • Non-Prescription
  • Safe & Effective


EQUELLE with active ingredient S-equol is a dietary supplement clinically shown to alleviate symptoms associated with menopause.
Hot Flashes

EQUELLE is clinically shown to help reduce the frequency of hot flashes.

Muscle Discomfort

Study participants experienced significant improvement in neck and shoulder muscle stiffness associated with menopause.1


S-equol has over 20 years of safety data, efficacy data and research.

Active Ingredient S-equol

Estrogen and S-Equol

EQUELLE contains naturally derived S-equol, a metabolite of the soy isoflavone daidzein, that binds to estrogen receptor beta (ERβ).1 ERβ is present in the hypothalamus, which controls body temperature processes and is, therefore, a target for helping ease vasomotor symptoms (VMS).2 The North American Menopause Society (NAMS) identifies S-equol as a potential option for alleviating vasomotor symptoms.3

Learn more about the
biological activity of S-equol

Estrogen and S-Equol

Clinical Support

In a clinical study, women taking a daily oral dose of EQUELLE (containing 10mg S-equol per dose) reduced their frequency of hot flashes by 58.7% after 12 weeks of treatment (n=77), significantly (p<0.01) more than the 34.5% reduction experienced in women receiving a placebo (n=83).1

Women receiving S-equol 10 mg/day (n=77) had significant improvements in the severity of their neck or shoulder muscle stiffness compared to placebo (n=83).4

Learn more about the latest
research studies on S-equol

Proven Safety Profile in Menopausal Women

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In clinical studies of Equelle, there were no major adverse events reported.1,4

The active ingredient S-equol is affirmed safe in both food and drug supplements. S-equol has 13-fold preference for binding to ERβ rather than for estrogen receptor α (ERα)5, which is present in the uterus and breast. Studies involving postmenopausal women who consumed the supplement containing S-equol have not observed any safety problems, including analysis of breast and uterine tissues and of hormone levels.1,4

View frequently asked
questions about S-equol

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Frequently Asked Questions

What is EQUELLE?

Hormone-free EQUELLE with plant-based S-equol helps reduce hot flashes and muscle aches associated with menopause.

Is EQUELLE clinically shown to be safe?

Is EQUELLE clinically shown to be effective?

What is the active ingredient in EQUELLE?

What is S-equol?

Who should NOT take EQUELLE?

Does EQUELLE require a prescription?