What is EQUELLE?
Hormone-free EQUELLE with plant-based S-equol helps reduce hot flashes and muscle aches associated with menopause.‡
About EQUELLE
EQUELLE with active ingredient S-equol is a dietary supplement clinically shown to alleviate symptoms associated with menopause.†
Hot Flashes
EQUELLE is clinically shown to help reduce the frequency of hot flashes.†
Muscle Discomfort
Study participants experienced significant improvement in neck and shoulder muscle stiffness associated with menopause.1
Safety
S-equol has over 20 years of safety data, efficacy data and research.
Active Ingredient S-equol
EQUELLE contains naturally derived S-equol, a metabolite of the soy isoflavone daidzein, that binds to estrogen receptor beta (ERβ).1 ERβ is present in the hypothalamus, which controls body temperature processes and is, therefore, a target for helping ease vasomotor symptoms (VMS).2 The North American Menopause Society (NAMS) identifies S-equol as a potential option for alleviating vasomotor symptoms.3
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biological activity of S-equol
Clinical Support
In a clinical study, women taking a daily oral dose of EQUELLE (containing 10mg S-equol per dose) reduced their frequency of hot flashes by 58.7% after 12 weeks of treatment (n=77), significantly (p<0.01) more than the 34.5% reduction experienced in women receiving a placebo (n=83).1
Women receiving S-equol 10 mg/day (n=77) had significant improvements in the severity of their neck or shoulder muscle stiffness compared to placebo (n=83).4
Learn more about the latest
research studies on S-equol
Proven Safety Profile in Menopausal Women
In clinical studies of Equelle, there were no major adverse events reported.1,4
The active ingredient S-equol is affirmed safe in both food and drug supplements. S-equol has 13-fold preference for binding to ERβ rather than for estrogen receptor α (ERα)5, which is present in the uterus and breast. Studies involving postmenopausal women who consumed the supplement containing S-equol have not observed any safety problems, including analysis of breast and uterine tissues and of hormone levels.1,4
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questions about S-equol