368 reviews

The only menopause relief supplement with S-equol, a plant-based ingredient that safely and naturally mimics estrogen — relieving hot flashes, improving sleep, and more 1.

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How to take Equelle

2 tablets in the morning

2 tablets in the evening

A safe alternative to hormone replacement

S-equol is derived from soy using a patented process and has been extensively studied and proven safe with:

No association with breast cancer
No changes in sex or thyroid hormones
No negative effects on endometrial health

Researched for over 20 years


more minutes of sleep 4


fewer hot flashes per day 2



How long will it take to feel effects of Equelle?

In clinical trials, Equelle provided menopause symptom relief as early as month 1, with optimal results in 2-3 months. Because S-equol works by safely mimicking estrogen in the body, it takes time to reach optimum results. The results on Equelle have been separately validated in 3 randomized, placebo-controlled clinical trials.

Your journey might be different than others, but this is a look at what other women experienced in clinical trials 1 :

  • The journey to symptom relief begins.
  • Women with frequent hot flashes reported daily hot flash relief and improvements in sleep quality in poor sleepers.
  • Women reported an average of 5 fewer hot flashes per day and experience a significant decrease in irritability.
  • Women reported an average of 50 minutes more sleep per night, improved vaginal symptoms like irritation, itching, and soreness, and significant improvements in overall mood.
  • After 12 weeks, 92% of women reports they were satisfied with Equelle.

Frequently Asked Questions

Fermented Soy Germ (S-equol source), Cellulose Gel, Calcium Phosphate, Stearic Acid, Sorbitol, Silicon Dioxide, Sodium Silicate, Croscarmellose Sodium, Organic Coating (Tapioca Maltodextrin, Sunflower Lecithin, Palm Oil, Guar Gum)

During menopause, estrogen levels decrease causing symptoms like hot flashes, sleep difficulties and vaginal irritation. Equelle's active ingredient, S-equol, has a similar structure as estrogen and can mimic some of its actions, helping to ease menopause symptoms.
How does Equelle work?

S-equol is the active ingredient in Equelle. It is a naturally derived compound produced through the fermentation of soy germ and is naturally produced by women in the gut in small amounts. The S-equol used in Equelle is developed using a patented fermentation process that simulates the specific gut conditions needed for certain bacteria to produce S-equol.

Taking Equelle does not impact estrogen levels. Although Equelle’s active ingredient, S-equol, mimics some of the same activities of estrogen by preferentially binding to estrogen receptor beta, Equelle is a dietary supplement free from human & animal hormones and clinical research shows S-equol supplementation reduces the frequency of hot flashes, supports the quality of sleep, reduces bothersome vaginal symptoms like irritation, soreness and itching, and alleviates mood swings.

Your body has two main types of estrogen receptors, called alpha receptors and beta receptors. Alpha receptors are primarily in your breast, ovarian, and uterine tissues. Beta receptors are primarily in places like the lining of your blood vessels and some parts of your brain. Estrogen, and estrogen hormone replacement therapies, bind to both alpha and beta receptors. S-equol has a similar molecular structure to estrogen but mostly binds to beta receptors.

By favoring these beta receptors, S-equol:
● Mimics the benefits of estrogen and relieves menopause symptoms
● Does not increase your risk for breast cancer and is not associated with changes in sex or thyroid hormones or endometrial health

Equelle and its active ingredient, S-equol, have undergone decades of clinical research and development. It has been shown to be safe and is not associated with changes in sex or thyroid hormones, negative effects on endometrial health or breast cancer. In general, taking botanicals or plant-based supplements may result in possible gastrointestinal upset. If you are experiencing any adverse effects, we recommend discontinuing product use and consulting your physician or healthcare professional.

Equelle is safe to take with other foods, supplements, and over-the-counter or prescription medications and will not negatively interact with them. However, Equelle should not be taken if you have a soy allergy or sensitivity. If you are pregnant, nursing, taking any medications and/or hormone therapy (HT), you should consult your healthcare professional before taking this product.

If you're experiencing menopause symptoms like hot flashes, sleep disturbances, vaginal discomfort, and more, Equelle is right for you whether you are in perimenopause, menopause, or postmenopause.

Real reviews from real women

This area allows women like you to express their own opinions and comments about Equelle. We stay out of it! These reviews are unfiltered and uncurated.

Customer Reviews
3.8 Based on 368 Reviews
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Barbara B.

Quick results

I have tried many other products but this one actually makes a difference. I'm sleeping better and my days are so much better. The hot flashes have reduced significantly. I highly recommend Equelle!

Edythe F.

While my hot flashes have

While my hot flashes have not gone away, they have decreased considerably I'm down to about 2-3 every night and 2-3 during the day which is much better than I was doing before.

Deanna C.

This product saved my life.

This product saved my life. No more hot flashes!! Feel like I am my thirtys again. I tell everyone about this product. Thank you Equelle!

Rhonda S.

Relief,but costly

Decreases night sweats Rather expensive

Kimberly A.

My hot flashes seem to

My hot flashes seem to have lessen in frequency since starting Equelle. I am going to keep trying for a few more months!